I’ve been using Fedora KDE since V40.

I have had some weird issues in the past where a network adapter randomly won’t work on startup a few years back, but haven’t had issues since.

Also back when I had a Nvidia GPU, I remember it having issues updating drivers due to not waiting long enough before restarting even though it said update complete and causing the driver the not work properly.

Those are really the only issues I’ve had with it, mostly just works for me personally.

After switching between distros for 8+ years and settling on Fedora KDE, I don’t think I’ve ever had SELinux get in my way for anything.